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<pubDate>Sat, 25 May 2013 18:38:25 -0700</pubDate>
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<title>Scientist found a way which Helps tone down Epileptic seizures</title>
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<description><![CDATA[ Injecting New Neurons Helps tone down Epileptic seizures.

When most people think of the nervous system, they think of it as a hub of activity. Sensations trigger nerves, which activate the ones they're connected to, eventually producing a response. What's often overlooked is the fact that shutting nerves down is just as important. Entire classes of nerves exist solely to tell their neighbors to quiet down, while Parkinson's disease is caused by the failure of a circuit that ultimately helps shut down muscle activity.

Another disease that's caused by excessive nerve activity is epilepsy, where the aberrant activation of nerves causes seizures. Researchers decided to try reversing this effect by adding additional inhibitory neurons, derived from embryonic cells, to specific regions of the brains of epileptic mice. The approach worked, which means their next step will probably involve trying to do the same thing with neurons derived from stem cells.

Although epilepsy is a complicated disease in humans, it's possible to model it in mice using a drug called pilocarpine, which activates receptors for the neurotransmitter acetylcholine. Used appropriately, pilocarpine is a valuable drug. But when given systemically (for example, injected into the blood stream), the drug enters the brain and causes excessive neural activity. This can result in long-term changes to the architecture of many neurons in the brain, creating a variety of symptoms that may include seizures, hyperactivity, and altered spatial memory.

To test their epilepsy treatment, the researchers injected mice with pilocarpine and monitored them around the clock for several days. Those that experienced a seizure were used for the study.

A number of inhibitory neuron types have been identified, but the authors were specifically interested in GABA-producing interneurons of the brain (GABA is an inhibitory neurotransmitter, and an interneuron is a nerve cell that establishes connections with other nerve cells). These are generated about two weeks into a mouse's embryonic development in a specific area of the early brain. To get a source of these GABA cells before they matured, the researchers simply dissected out that part of the embryonic brain. To make sure they could find these cells in the adult animals, the mice were genetically tagged with a gene that makes a fluorescent protein.

"Embryonic cells turn into inhibitory neurons that block aberrant activity" ]]></description>
<pubDate>Tue, 21 May 2013 01:12:21 -0700</pubDate>
<guid>http://indigg.com/science/scientist-found-a-way-which-helps-tone-down-epileptic-seizures/</guid>
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